Skin microbiota is an important effector in the host physiology and immunity. Bacteria coming from human skin swabs have been shown to be coated with immunoglobulins, and recent studies have also identified mature class-switched B cells in homeostatic human skin. In this study, the authors demonstrate a unique feature of skin immune autonomy in supporting a humoral response able to constrain the local biomass of the microbiota as well as subsequent systemic infection. This work reveals a function for the skin as a compartment in the absence of inflammation able to develop powerful antibody responses independently of secondary lymphoid organs.
Suggested by Emanuela Di Campli