Global transmission of extended-spectrum cephalosporin resistance in Escherichia coli driven by epidemic plasmids
Extended-spectrum cephalosporins (ESCs) are third and fourth generation cephalosporin antimicrobials used in humans and animals to treat infections due to multidrug-resistant bacteria, but their effectiveness has been compromised due to the emergence of resistant Escherichia coli strains. This resistance is often mediated by plasmids, some of them, called “epidemic plasmids”, played a significant role in the global dissemination of antibiotic resistance. These plasmids contain genes encoding extended-spectrum β-lactamases, enzymes that can degrade ESCs, making them ineffective. This study highlights the need for global surveillance, better antibiotic management and strategies to control the spread of these resistance genes, as the global spread of these resistant strains threatens the effectiveness of essential antibiotics.
Suggested by Emanuela Di Campli