Helicobacter pylori is a Gram-negative bacterium capable of colonizing the human gastric mucosa and contributing to the development of several gastric disorders. H. pylori is also known for its persistent infections, often due to the failure of conventional therapies or for its ability to internalize within multiple cell types. New evidence suggests that Candida cells may act as a reservoir for H. pylori, potentially protecting the bacterium from hostile environmental conditions and contributing to the establishment of cross-kingdom interactions.
This study investigates the intrinsic association between H. pylori and Candida using several H. pylori-related assays on Candida clinical isolates. The results suggest that Candida can harbour H. pylori‑related material and traits, including urease activity and the expression of bacterial genes such as 16S rRNA and ureA, while the fluorescent staining revealed intracellular signals compatible with viable H. pylori.
Overall, these findings support the hypothesis that Candida may act as a reservoir that facilitates the persistence of H. pylori.
Suggested by Dr. Morena Pinti