This study explores the antimicrobial and anti-virulence effects of a natural compound, Methylglyoxal (MGO), alone and in combination with novel technologies, such as Light-Emitting Diodes (LED) and Complex Magnetic Fields (CMFs) against multidrug resistant clinical isolated of Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans from chronic wounds. The study demonstrates that these non-antibiotic approaches can affect negatively microbial viability, membrane permeability, and motility, and that MGO may interfere with bacterial enzymes such as urease. The results suggest that the combination of these strategies could significantly improve the effectiveness of antimicrobial treatments against resistant pathogens, while also ensuring safety for host tissues and promoting environmental sustainability due to the use of non-antibiotic and low-impact technologies.
Suggested by Prof. Simonetta D’Ercole