Helicobacter pylori, a human pathogen responsible of severe gastroduodenal disease, is characterized by multi-drug resistance that is the main cause of the Helicobacter pylori eradication failure. For this reason, it is mandatory to find new strategies to improve the H. pylori therapy management. In this review, substances like A,D,C,E,B6,B9,B12 vitamins and minerals such as zinc, iron, copper, nichel and selenium have been proposed as compounds able to affect the H. pylori infection and to enhance the eradication rate. In fact, micronutrient supplementations increased the efficiency to eradication and reduced both the risk of drug-related adverse effects and the oxidative stress inflammation thanks to their antioxidant properties.
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