Chronic wounds, such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers are strongly influenced by the wound microbiome, which shapes inflammation, immune responses, and healing outcomes. Chronic wounds are characterized by dysbiosis, reduced microbial diversity, and proliferation of pathogens like Staphylococcus aureus and Pseudomonas aeruginosa, often organized in biofilms.
Biofilms are characterized by highly resilient microbial consotia, tolerant to antimicrobial therapy able to impair host immune defenses.Advances in NGS, metagenomics, and multi‑omics allow better characterization of bacteria, fungi, and viruses, identifying microbials linked to healing or chronicity.
Emerging microbioma modulating strategies including probiotics, bacteriophages, topical oxygen therapy, nanomaterials, can be a good suggestion to shift wound ecosystem towards in a pro-healing state.
Overall, the wound microbiome can be considered both a biomarker and a therapeutic target, with potential to guide personalized wound care.
Suggestest by Prof.ssa Luigina Cellini